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A Journal on Internal Medicine
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,236
Minerva Medica 2014 February;105(1):51-6
Clinical and experimental observations of peripheral blood leukocytes and nucleated bone marrow cells after local irradiation
Zhang X.-G. 1, Du A.-N. 1, Geng C. 1, Guo F. 2, He M. 1, Gu F. 1, Wang J. 1, Song W.-B. 1, Xu H. 1, Sheng W. 1, Liu Y. 1, Ye T. 1 ✉
1 Department of Hematology, Jiangsu University Affiliated Xuzhou Hospital (Xuzhou Tumor Hospital), Xuzhou, China;
2 Department of Clinical Laboratory, Jiangsu University Affiliated Xuzhou Hospital (Xuzhou Tumor Hospital), Xuzhou, China
Aim: Aim of the study was to observe the impact of bone marrow damage induced by local irradiation on leukopenia.
Methods: For the human study, five cancer patients received local radiation therapy. Bone marrow aspiration was conducted to measure nucleated cell count and 99mTc-Sc sulfur colloid ECT imaging was carried out to examine bone marrow function. For the animal study, fifty New Zealand white rabbits were divided into 3 groups: non-irradiated control group (N.=10), abdomen irradiation group (irradiation area did not cover bone marrow) (N.=20), chest irradiation group (irradiation area covered bone marrow) (N.=20). Nucleated cell counts were taken after confirming onset of leukopenia.
Results: Bone marrow of five patients proliferated normally. ECT imaging showed no abnormality in the pattern of red bone marrow distribution. Hematopoietic function was mildly active.
Conclusion: Suppressed myeloproliferative function does not fully account for irradiation-induced leukopenia.