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A Journal on Internal Medicine
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,236
Minerva Medica 2013 August;104(4):431-8
A polymorphism in the resistin gene promoter and the risk of multiple sclerosis
Hossein-Nezhad A. 1, 2, Varzaneh F. N. 1, Mirzaei K. 1, Emamgholipour S. 1, Varzaneh F. N. 1, Sahraian M. A. 3 ✉
1 Tehran University of Medical Sciences, Tehran, Iran;
2 Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Department of Medicine, Boston University Medical Center, Boston, MA, USA;
3 Sina MS Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
Aim: Multiple sclerosis (MS) is an inflammatory neurodegenerative disorder that inflammatory cytokines have been implicated in its immunopathogenesis. Resistin, a member of cysteine-rich secretory proteins family, identified with inflammatory properties in humans. To elucidate whether different genotypes of resistin are involved in MS pathogenesis, we compared serum levels of TNF-α, IL-1β, hs-CRP, and resistin levels in different genotypes of MS patients with relapsing remitting type and healthy subjects.
Methods: In a case-control study, 86 MS patients and 86 age- and sex-matched healthy subjects were enrolled. The age, gender distribution, and BMI of MS patientsand control group were similar. The serum levels of TNF-α, IL-1β, and Resistin were measured by ELISA. hs-CRP was measured by imunoturbidimetric method. After DNA extraction, the analysis of -420C/G SNP (rs1862513) was performed via PCR-RFLP method.
Results: The resistin, TNF-α, IL1β, and hs-CRP levels were significantly higher in MS patients compared with control group. The distribution of “rs1862513” genotypes were not significant between MS and control groups. Although resistin and TNFα levels were higher in GG genotype carriers of both groups, but the difference was significant only in MS patient.
Conclusion: Resistin gene polymorphisms may modify the being susceptible to MS disease, which may cause through various levels of cytokines between genotypes.