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A Journal on Internal Medicine


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Minerva Medica 2012 August;103(4):323-9

language: English

Circulating levels of adiponectin, orexin-A, ghrelin and the antioxidant paraoxonase-1 in metabolic syndrome

Tabak Ö. 1, Gelişgen R. 2, Çicekçi H. 2, Şenateş E. 3, Erdenen F. 1, Müderrisoğlu C. 1, Aral H. 4, Uzun H. 2

1 Istanbul Education and Research Hospital Internal Medicine Clinic, Istanbul, Turkey;
2 Department of Biochemistry, Istanbul University Cerrahpasa Medical Faculty Istanbul, Turkey;
3 Department of Gastroenterology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey;
4 Biochemical Laboratory, Istanbul Education and Research Hospital Istanbul, Turkey


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AIM: Metabolic syndrome (MS) is a disorder consisting of various abnormalities such as dyslipidemia, obesity, hypertension and hyperglycemia. Over the past two decades, the prevalence of MS has greatly increased, and it has become a global health problem. We measured and compared plasma concentrations of adiponectin, orexin-A, ghrelin and the antioxidant paraoxonase-1 (PON1) between patients with metabolic syndrome (MS) and healthy controls.
MTHODS: A total of 87 patients (46 women, 41 men) with MS and 40 healthy controls (21 women, 19 men) with a BMI less than 25 kg/m2 were enrolled in the study. The plasma concentrations of the adiponectin, orexin-A, ghrelin and PON1 were meaured by ELISA.
RESULTS: Plasma concentrations of Orexin-A were significantly higher in patients with MS than controls (P<0.001). However, plasma concentrations of adiponectin, ghrelin and PON1 were significantly lower in patients with MS compared to controls (P<0.001, P<0.001 and P<0.001, respectively).
CONCLUSION: Our data confirmed the previous findings that plasma concentrations of orexin-A is higher than controls, however plasma concentrations of PON1, ghrelin and adiponectin are lower compared to controls.

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