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A Journal on Internal Medicine
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,236
Minerva Medica 2012 June;103(3):183-7
IgG-anti-IgA antibdies: an autoimmune finding in patients with psoriasis vulgaris
Azarsiz E. 1, Ertam I. 2, Karaca N. 1, Aksu G. 1, Alper S. 2, Kutukculer N. 1 ✉
1 Department of Pediatric Immunology, Ege University Medical School, Izmir, Turkey;
2 Department of Dermatology, Ege University Medical School, Izmir, Turkey
AIM: Psoriasis is thought to be an autoimmune disease caused by inappropriate activation of the cellular immune system. In this study, we aimed to search out IgG-anti-IgA antibody levels, serum immunoglobulins and antinuclear antibodies (ANA).
METHODS: The study entrolled 38 psoriasis vulgaris patients and 40 healthy controls.
RESULTS:Mean IgG-anti-IgA levels were significantly higher in psoriasis patients. The frequency of positive ANA testing was 21.1%; however, there was no correlation between IgG-anti-IgA antibody levels and ANA positivity. Only one patient had low IgA levels without high IgG-anti-IgA concentrations.
CONCLUSION:The data about high IgG-anti-IgA antibody levels are noteworthy for a new evidence of autoimmune mechanism.