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A Journal on Internal Medicine

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Minerva Medica 2012 February;103(1):37-46

language: English

Ovarian cryopreservation

Jeong K. 1, Aslan E. 2, Ozkaya E. 2, Sonmezer M. 3, Oktay K. 2

1 Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, Korea;
2 Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, Westchester Medical Center, New York Medical College, Valhalla, NY, USA;
3 Center for Research on Human Reproduction, Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey


Cryopreservation of ovarian tissue and future autotransplantation are new promising strategies for fertility preservation in various malignant and non-malignant diseases facing the risk of ovarian failure. Ovarian cortrical tissue pieces or intact whole ovary can be removed by laparoscopy without any significant delay in chemotherapy. Slow freezing and vitrification methods are developed to avoid damage to follicles. Ovarian tissue can be transplanted in an orthotopic or heterotopic location when the patient is cured from the disease. Autotransplantation can be performed if absence of malignant cells in the graft is confirmed. Although the procedures are still experimental, ovarian cryopreservation is the single option in prepubertal girls who have not sexual maturity. Earlier team approach of oncologists and reproductive endocrinologists may provide a more successful and professional way of fertility preservation.

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