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A Journal on Internal Medicine

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Minerva Medica 2010 October;101(5):363-70

language: Italian

Thyroid function and obesity

Garnerone L., Iorio L., Zelaschi R., Delnevo A., Tufano A., Ambrosi B.

1 Unità Operativa di Endocrinologia e Diabetologia, Dipartimento di Scienze Medico-Chirurgiche, IRCCS Policlinico San Donato
Università degli Studi di Milano, Milano, Italia;
2 Scuola di Specializzazione in Scienze dell’Alimentazione, Dipartimento di Chimica, Biochimica e Biotecnologie per la Medicina
Università degli Studi di Milano, Milano, Italia


A relationship between thyroid function and obesity seems likely, mainly influenced by the insulin resistance. Whether variations in TSH and/or thyroid hormones, within a normal range, can influence body weight or if obesity per se can alter thyroid function has not been clarified so far. Further studies are necessary to assess the link between thyroid function and body weight, that must consider not only changes of thyroid hormones, but also body fat distribution, obesity duration and the state of low grade inflammation. It is recognized that thyroid function is linked not only to body mass index, but also to body composition and, particularly, to the amount and percentage of fat mass.

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