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Minerva Medica 2010 October;101(5):305-10

language: English

Evaluation of oxidative and nitrosative stress in hemodialysis patients

Namiduru E.-S. 1, Tarakçiog˘lu M. 1, Tıryakı Ö. 2, Usalan C. 2

1 Department of Biochemistry, Faculty of Medicine, University of Gaziantep Gaziantep, Turkey;
2 Department of Nephrology, Faculty of Medicine, University of Gaziantep Gaziantep, Turkey


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AIM: Oxidative/nitrosative stress has long been demonstrated in hemodialysis patients. It is associated with numerous complications such as atherosclerosis and related cardiovascular disturbances. However, the factors influencing oxidative/nitrosative status have not been characterized extensively in these patients. Therefore, the present study was designed to investigate the alteration of oxidative/nitrosative stress parameters and total antioxidant status.
METHODS: Forty-one hemodialysis patients and 41 healthy subjects were enrolled in the present study. Serum myeloperoxidase, nitrotyrosine and total antioxidant capacity were determined.
RESULTS: Serum myeloperoxidase and nitrotyrosine were significantly higher in the haemodialysis patients compared to the healthy subjects (P<0.05) while total antioxidant capacity was lower (P<0.01).
CONCLUSION: According to the results of this study, oxidative and nitrosative stress is increased in haemodialysis patients, therefore these alterations should be considered in the treatment of these patients.

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enamiduru@gmail.com