Home > Journals > Minerva Medica > Past Issues > Minerva Medica 2009 October;100(5): > Minerva Medica 2009 October;100(5):401-13





A Journal on Internal Medicine

Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,236




Minerva Medica 2009 October;100(5):401-13

language: English

Cryopreservation of ovarian tissue: an overview

Donnez J., Dolmans M.-M.

Department of Gynecology, Catholic University of Louvain, Brussels, Belgium


Advances in the diagnosis and treatment of childhood, adolescent and adult cancer have greatly increased the life expectancy of premenopausal women with cancer. The ovaries are very sensitive to cytotoxic treatment, especially to alkylating agents. The only established method of fertility preservation is embryo cryopreservation according to the Ethics Committee of the American Society for Reproductive Medicine (2005), but this option requires the patient to be of pubertal age, have a partner or use donor sperm, and be able to undergo a cycle of ovarian stimulation, which is not possible when the chemotherapy has to be initiated immediately or when stimulation is contraindicated according to the type of cancer. For patients who need immediate chemotherapy, cryopreservation of ovarian tissue is the only possible alternative. This manuscript reports the techniques and results of orthotopic transplantation of cryopreserved ovarian tissue. Among almost 30 cases reported in the literature, seven live births have been achieved to date.

top of page

Publication History

Cite this article as

Corresponding author e-mail