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A Journal on Internal Medicine

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Minerva Medica 2008 June;99(3):253-62

language: English

Insulin resistance and the metabolic syndrome

Lann D., Gallagher E., LeRoith D.

Division of Endocrinology, Diabetes and Bone Diseases Department of Medicine Mount Sinai School of Medicine, New York, USA


The metabolic syndrome is a constellation of risk factors including glucose dysregulation, central obesity, dyslipidemia, and hypertension. There are multiple definitions that have been described by various health organizations. However, we do know that insulin resistance plays a major role as the underlying cause for the development and potentiation of the metabolic syndrome. At present, it is unclear if the diagnosis of metabolic syndrome is greater than the sum of its parts. However, the presence of more than one of the associated risk factors should indicate that a patient is at increased risk for developing diabetes, cardiovascular disease and death. Thus, the primary care physician should aggressively treat the metabolic risk factors in their patients to prevent the onset and progression to more severe disease.

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