Home > Journals > Minerva Medica > Past Issues > Minerva Medica 2008 April;99(2) > Minerva Medica 2008 April;99(2):213-8

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA MEDICA

A Journal on Internal Medicine


Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,878


eTOC

 

CASE REPORTS  


Minerva Medica 2008 April;99(2):213-8

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: English

A singular case of granulomatous lesions of unknown significance

Danese C., Cirene M., Colotto M.

Department of Clinical Science Umberto I Hospital Complex University “La Sapienza” Rome, Italy


PDF  


The acronym used for granulomatous lesion of unknown significance, (GLUS), was first employed in 1990, to describe epithelioid-cell granulomas occasionally observed in biopsies from liver, lymph-nodes and other tissues without any apparent cause than thorough diagnostic examinations. Authors describe a case of a 51-year-old woman who was admitted to hospital because of fever, nodules in the liver and spleen, skin ulcerative lesions on the legs. The patient had a very long medical history; recurrent fever, liver and spleen enlargement have been lasting since 1975. Laboratory data showed erythrocyte sedimentation rate increase (125 mm 1 hour), anemia, (Hb=8.1 g/dL), an increase of alkaline phosphatase activity (328.4 mU/mL NV=80-275) and also an increase of policlonal g-globulins; patient’s total proteins was 6.8 g/dL while their g-globulins were 29.5%; IgG=2 260 mg/dL (NV=751-1 560 mg/dL), IgM=277 mg/dL (NV=46-230 mg/dL), IgA=405 mg/dL (NV=70-400 mg/dL). One culture of the blood and a needle aspiration specimen of liver nodule was positive for Staphylococcus coagulase negative. This case cannot be regarded as GLUS-syndrome because of the long time duration of the disease and other clinical features. The dramatic, even if transient, liver nodules improvement obtained by Linezolid therapy, and the well-being obtained by prolonged monociclin use, make the authors hyopothesize that Staphylococcus coagulase negative could be the etiological agent of this granulomatous clinical picture.

top of page

Publication History

Cite this article as

Corresponding author e-mail