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Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,236
Online ISSN 1827-1669
Cappuccio G. 1, Valesio R. 1, Lamorgese V. 1, Massucco S. 1, Varetto G. 2, Conforti M. 2, Casella F. 2, Monti A. 2, Rispoli P. 2
1 U.O. Riabilitazione Cardiovascolare Casa di Cura Villa Serena, Piossasco, Torino
2 Cattedra di Chirurgia Vascolare Università degli Studi di Torino, Torino
Activated C protein resistance is a common coagulation defect caused by factor V Leiden mutation and is associated with an augmented risk of predominantly venous thrombosis. Augmented tendency to arterial thrombosis is sporadically reported. This case report describes femoropopliteal thrombosis in a young patient with heterozygous V Leiden factor mutation. Progressive thrombotic occlusion required amputation of the forefoot which resulted in stump dehiscence. Poor blood supply to the perilesional substrate delayed wound healing. An optimal though not yet definitive result was achieved after months of accurate medication. The criticality of lower limb ischemia in an otherwise healthy young patient underscores the grave impact this condition can have on the patient’s quality of life and on health care costs.