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A Journal on Internal Medicine

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Minerva Medica 2007 February;98(1):1-4

language: Italian

Hepatitis c virus and type 2 diabetes mellitus

Guglielmi V. 1, Tutino M. 2, Guerra V. 3

1 Unità Operativa Complessa di Gastroenterologia ed Endoscopia Digestiva IRCCS S. De Bellis, Castellana Grotte (BA)
2 Centro Elaborazione Dati IRCCS S. De Bellis, Castellana Grotte (BA)
3 Servizio di Epidemiologia IRCCS S. De Bellis, Castellana Grotte (BA)


Aim. In literature there are many reports on hepatitis C virus (HCV) and type 2 diabetes mellitus association. However, many authors have proved this association in anti-HCV positive patients affected by cirrhosis. Thus, type 2 diabetes mellitus has been associated to cirrhosis rather than to HCV.
Methods. We wanted to verify the type 2 diabetes mellitus prevalence in 3 606 anti-HCV positive patients both cirrhotic and noncirrhotic. The results obtained have been compared with those of 1 053 HBsAg positive patients. All the patients were hospitalised for the first time in our institute between January 1991 and December 2003.
Results. Type 2 diabetes mellitus is more frequently associated to cirrhotic rather than to noncirrhotic patients, but between the 2 groups of patients (anti-HCV and HBsAg positive) HCV increases type 2 diabetes mellitus association significantly.
Conclusion. Hepatic cirrhosis and HCV make easier the onset of type 2 diabetes mellitus.

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