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Minerva Medica 2006 December;97(6):487-94

Copyright © 2006 EDIZIONI MINERVA MEDICA

Hypolipidaemia is not always indicating liver dysfunction. A review of primary and secondary high density lipoprotein and low density lipoprotein deficiencies

Andrikoula M. 1, Avades T. 2

1 Department of Endocrinology University Hospital of Ioannina, Ioannina, Greece 2 Department of Medical Biochemistry University Hospital of Wales, Cardiff, UK


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Hypolipidaemias can be either primary due to several genetic defects altering the serum concentration of lipoproteins, or secondary resulting from various disorders such as liver disease, malabsorption, malnutrition, malignancy, hyperthyroidism and immunoglobulin disorders. We present a review of the current knowledge regarding the various causes of hypolipidaemias. Our aim is to emphasize on the differrent mechanisms, apart from deranged liver synthetic function, that are responsible for unusually low levels of cholesterol and on the disorders that need to be considered during the investigation of hypolipidaemia.

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