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Minerva Medica 2006 October;97(5):437-42

Copyright © 2006 EDIZIONI MINERVA MEDICA

language: English, Italian

Decreased chemiluminescence in leukocyte adhesion deficiency presenting with recurrent sepsis, amoebiasis and Candida albicans urinary tract infection

Valentini P. 1, De Sole P. 2, De Luca D. 1, Plaisant P. 3, Puggioni P. 4, Rossi M. C. 2, Rumi C. 4, Ranno O. 1

1 Pediatric Infectious Disease Unit Department of Pediatrics Sacro Cuore Catholic University, Rome, Italy 2 Chemiluminescence Laboratory Department of Chemistry and Clinical Chemistry Sacro Cuore Catholic University, Rome, Italy 3 Department of Microbiology, Sacro Cuore Catholic University, Rome, Italy 4 1Flow-Cytofluorimetry Study Center Department of Haematology Sacro Cuore Catholic University, Rome, Italy


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Leukocyte adhesion deficiency (LAD) is a rare disorder of cellular immunity, generally due to various mutations producing reduced or altered expression of membrane integrins. The authors report a case of LAD due to integrins expression imbalance. LAD was suspected after recurrent sepsis, fungine infection and amoebiasis with persistent leukocytosis. Neutrophils were studied with chemiluminescence showing decreased functional activity: up to now, this seems the first chemiluminescence study of neutrophil function and the first report of amoebiasis at the onset in LAD.

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