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Home > Journals > Minerva Medica > Past Issues > Minerva Medica 2006 October;97(5) > Minerva Medica 2006 October;97(5):437-42



A Journal on Internal Medicine

Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,236

Frequency: Bi-Monthly

ISSN 0026-4806

Online ISSN 1827-1669


Minerva Medica 2006 October;97(5):437-42


Decreased chemiluminescence in leukocyte adhesion deficiency presenting with recurrent sepsis, amoebiasis and Candida albicans
urinary tract infection

Valentini P. 1, De Sole P. 2, De Luca D. 1, Plaisant P. 3, Puggioni P. 4, Rossi M. C. 2, Rumi C. 4, Ranno O. 1

1 Pediatric Infectious Disease Unit Department of Pediatrics Sacro Cuore Catholic University, Rome, Italy
2 Chemiluminescence Laboratory Department of Chemistry and Clinical Chemistry Sacro Cuore Catholic University, Rome, Italy
3 Department of Microbiology, Sacro Cuore Catholic University, Rome, Italy
4 1Flow-Cytofluorimetry Study Center Department of Haematology Sacro Cuore Catholic University, Rome, Italy

Leukocyte adhesion deficiency (LAD) is a rare disorder of cellular immunity, generally due to various mutations producing reduced or altered expression of membrane integrins. The authors report a case of LAD due to integrins expression imbalance. LAD was suspected after recurrent sepsis, fungine infection and amoebiasis with persistent leukocytosis. Neutrophils were studied with chemiluminescence showing decreased functional activity: up to now, this seems the first chemiluminescence study of neutrophil function and the first report of amoebiasis at the onset in LAD.

language: English, Italian


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