Home > Journals > Minerva Medica > Past Issues > Minerva Medica 2006 February;97(1) > Minerva Medica 2006 February;97(1):31-8

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA MEDICA

A Journal on Internal Medicine


Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,236


eTOC

 

REVIEWS  HELICOBACTER PYLORI: THE BACTERIUM OF 2005 NOBEL PRIZE


Minerva Medica 2006 February;97(1):31-8

language: Italian

Gastric cancer and Helicobacter pylori: an interdisciplinary point of view

Pellicano R. 1, Mladenova I. 2, Martinotti R. 3, Fagoonee S. 4, Rizzetto M. 1

1 S.C.D.U. Gastro-Epatologia Azienda Ospedaliera San Giovanni Battista, Torino
2 Department of Epidemiology Medical Faculty University of Stara Zagora, Stara Zagora, Bulgaria
3 Centro Universitario Ricerche Oncologiche (CURO) Azienda Ospedaliera San Giovanni Battista, Torino
4 Dipartimento di Biologia, Biochimica e Genetica Università degli Studi di Torino, Torino


PDF  


Gastric carcinogenesis involves a slow but continuous, stepwise evolution from superficial gastritis to glandular atrophy, metaplasia, dysplasia, and finally, to adenocarcinoma. In 1994, the International Agency for Research on Cancer defined Helicobacter pylori (H. pylori) as a group I carcinogen. Evidence supporting a causal association has been demonstrated by epidemiological data as well as by experimental animal models. The process of carcinogenesis, which may well extend over decades, provides an excellent opportunity for prevention or early detection of the events preceding development of the neoplasm. This is especially true because, at present, H. pylori can be readily treated. Despite this, the prognosis for gastric cancer is poor and, in most industrialised countries, the survival is only 10% after 5 years from diagnosis. The sole exception is Japan where this malignancy is often identified at an early stage when cure by radical surgery is more probable.

top of page

Publication History

Cite this article as

Corresponding author e-mail