Home > Journals > Minerva Medica > Past Issues > Minerva Medica 2004 April;95(2) > Minerva Medica 2004 April;95(2):93-104

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA MEDICA

A Journal on Internal Medicine


Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,878


eTOC

 

REVIEWS  


Minerva Medica 2004 April;95(2):93-104

Copyright © 2004 EDIZIONI MINERVA MEDICA

language: English

Gene therapy for type 1 diabetes. New approaches

Morral N.


PDF  


Type 1 or insulin-dependent diabetes mellitus is a metabolic disease that results from the destruction of pancreatic b-cells. Most patients receive subcutaneous insulin injections to reduce blood glucose levels. However, strict glucose control by multiple insulin injections is associated with an increased risk of hypoglycemia and weight gain, while a less strict glucose control is insufficient to prevent chronic complications such as nephropathy, neuropathy and retinopathy. Gene therapy holds a tremendous therapeutic potential to improve glycemic control by restoring endogenous insulin production. This review focuses on recent advances directed at producing insulin in an ectopic tissue as well as inducing pancreatic b-cell neogenesis. The strategies include constitutive and promoter-regulated insulin expression in the liver; increasing hepatic glucose oxidation; insulin production from intestinal cells; and islet cell neogenesis in liver and pancreas.

top of page

Publication History

Cite this article as

Corresponding author e-mail