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A Journal on Internal Medicine

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Minerva Medica 2001 June;92(3):155-60

language: Italian

Determinazione degli oppiacei nelle urine, interpretazione del confronto tra EIA e FPIA e conferma dei dati con GC/MS

Giusiani M., Viviani P.


Background. The aim of this study was to evaluate some urine samples and to analyse them using two immunochemical screening me-thods.
Methods. A more reliable method has been used to obtain a critical analysis of the validity of the ''first analysis'' methods used. A total of 147 urine samples were examined using both the FPIA technique (Adx, Abbott) and the EIA technique (Random 120, Bracco); confirmation was obtained using GC/MS.
Results. When the threshold was altered from 200 to 300 ng/ml the EIA technique is more severely affected by changes in reference values compared to FPIA. In different values between two techniques, confirmation with GC/MS was possibile only 5 cases.
Conclusions. The study of data processing with immunochemical tests and after confirmation showed that the results with GC/MS are closer to Adx. The FPIA results are in agreement with the GC/MS technique both at 200 and 300 ng/ml with a percentage of 80.0%. The EIA technique has a different result, at 200 ng/ml it is in agreement for 40.0%, but at 300 ng/ml there is only 20.0%.

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