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Minerva Medica 2001 June;92(3):151-4

language: Italian

Observations on the increased serum levels of glycoprotein YKL-40 in patients with rheumatoid arthritis and osteoarthritis

Morgante M., Metelli M. R., Morgante D.


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Background. This study aimed to evaluate the function of glycoprotein YKL-40 in patients with rheumatoid arthritis, erosive osteoarthrosis or coxitis.
Methods. Serum levels of glycoprotein YKL-40 were assayed using an ELISA method in 40 patients with active-phase rheumatoid arthritis and 20 patients suffering from erosive osteoarthrosis or coxitis.
Results. The mean values of YKL-40 were enhanced in all patients with rheumatoid arthritis and arthrosis with higher mean values in erosive osteoarthritis and coxitis (440 ng/ml) compared to rheumatoid arthritis (190 ng/ml).
Conclusions. YKL 40 is a local prognostic marker of joint destruction.

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