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Minerva Medica 2000 January-February;91(1-2):17-30

Copyright © 1999 EDIZIONI MINERVA MEDICA

language: Italian

Prognostic factors in the treatment of advanced carcinoma of the cervix. A retrospective analysis

Sacco M., Tessa M., Rampino M., Ragona R., Airaldi C., Nassisi D., Rondi N., Gatti M., Garnero G., Rotta P.


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Background. The value of prognostic factors in patients with advanced cervix carcinoma treated by radiotherapy was assessed in a retrospective study. Methods. From January 1977 through Decem-ber 1990, 261 patients (average age 60 years) were treated at the Radiotherapy Department of the University of Turin. Distribution by stage was: 142 T2b (54%),8 T3a (3%),98 T3b (38%) and 13 T4 (5%). 83% of the patients underwent radiotherapy alone; the total dose was 45-88 Gy in 91 patients (42%) with poor clinical conditions, 60-75 Gy in 121 (56%) and 75-80 Gy in 5 cases. 17% of the patients was treated by surgery combined with radiotherapy. The median follow-up was 50 months (minimum 2, maximum 177 months).Results. The 5-year NED survival and local control were 42% (52% for T2b, 33% for T3 and 15% for T4).The severe (G3-G4) complication rate was very low (1.9%).Conclusion. In our series, the prognostic factors which significantly influenced survival in the uni-variate analysis were: advanced T stage, contemporary infiltration of parametrium and vagina, nodal status, non squamous neoplasm, younger age and the absence of brachytherapy in the radiotherapy alone protocol.

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