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A Journal on Internal Medicine

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Minerva Medica 2000 January-February;91(1-2):17-30

language: Italian

Prognostic factors in the treatment of advanced carcinoma of the cervix. A retrospective analysis

Sacco M., Tessa M., Rampino M., Ragona R., Airaldi C., Nassisi D., Rondi N., Gatti M., Garnero G., Rotta P.


Background. The value of prognostic factors in patients with advanced cervix carcinoma treated by radiotherapy was assessed in a retrospective study. Methods. From January 1977 through Decem-ber 1990, 261 patients (average age 60 years) were treated at the Radiotherapy Department of the University of Turin. Distribution by stage was: 142 T2b (54%),8 T3a (3%),98 T3b (38%) and 13 T4 (5%). 83% of the patients underwent radiotherapy alone; the total dose was 45-88 Gy in 91 patients (42%) with poor clinical conditions, 60-75 Gy in 121 (56%) and 75-80 Gy in 5 cases. 17% of the patients was treated by surgery combined with radiotherapy. The median follow-up was 50 months (minimum 2, maximum 177 months).Results. The 5-year NED survival and local control were 42% (52% for T2b, 33% for T3 and 15% for T4).The severe (G3-G4) complication rate was very low (1.9%).Conclusion. In our series, the prognostic factors which significantly influenced survival in the uni-variate analysis were: advanced T stage, contemporary infiltration of parametrium and vagina, nodal status, non squamous neoplasm, younger age and the absence of brachytherapy in the radiotherapy alone protocol.

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