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MINERVA GINECOLOGICA

A Journal on Obstetrics and Gynecology


Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index


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Minerva Ginecologica 2017 August;69(4):390-401

DOI: 10.23736/S0026-4784.17.04049-7

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

The role of seminal fluid in infertility

Justin BONNICI, Adrian FENECH, Craig MUSCAT, Jean CALLEJA-AGIUS

Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta


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Approximately 15% of couples worldwide are considered infertile, with up to 50% due to a defect in the male reproductive physiology. Many of these latter defects are idiopathic or genetically related and mostly focused on the spermatozoon and as such, the majority of studies to date have focused mainly on disorders related with the sperm cell. In this review, the importance of seminal fluid integrity and its effect on the female reproductive physiology is described in the context of male infertility. Human seminal plasma contains a vast array of proteins which are required for an optimal physiological function of the sperm and their effect on the female reproductive physiology. Moreover, proteins are being extensively investigated as biomarkers for diseases such as prostate cancer and male infertility. This may give an indication to the best choice of ART the individual male should opt for when partners choose to start a family.


KEY WORDS: Biomarkers - Semen - Infertility, male - Reproductive techniques, assisted

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Publication History

Issue published online: June 8, 2017
Article first published online: April 10, 2017
Manuscript accepted: April 4, 2017
Manuscript received: March 6, 2017

Cite this article as

Bonnici J, Fenech A, Muscat C, Calleja-Agius J. The role of seminal fluid in infertility. Minerva Ginecol 2017;69:390-401. DOI: 10.23736/S0026-4784.17.04049-7

Corresponding author e-mail

jean.calleja-agius@um.edu.mt