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MINERVA GINECOLOGICA

A Journal on Obstetrics and Gynecology


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Minerva Ginecologica 2017 August;69(4):336-41

DOI: 10.23736/S0026-4784.17.04074-6

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: Italian

Evaluation of the effects of a natural dietary supplement with cranberry, noxamicina® and d-mannose in recurrent urinary infections in perimenopausal women

Vincenzo DE LEO , Valentina CAPPELLI, Maria G. MASSARO, Claudia TOSTI, Giuseppe MORGANTE

Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy


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BACKGROUND: The female genital apparatus, the urinary tract and the perineal supporting tissues share a common embryological origin, whose differentiation depends on the action of estrogens. In adult women, the progressive decline of the ovarian function, with the ensuing estrogen deprivation, reduces tissue tropism causing urogenital atrophy, which makes these organs much more susceptible to traumatisms and urinary infections. The disorders associated with changes in the urogenital tract of peri- and postmenopausal women have significant clinical relevance, both on account of their chronicity and high frequency of occurrence and on account of their having major repercussions on the quality of life of the women, who often have to call their doctor seeking relief for their symptoms. In general, these patients report having a significant number of episodes of cystitis per year. With a view to verifying whether the use of a new dietary supplement (Kistinox® Forte sachets) containing cranberry (Vaccinium macrocarpon), Noxamicina® (propolis extract) and D-mannose can be of use in the treatment of cystitis, with or without bacteriuria, through the elimination of urinary symptoms, a multicenter clinical study was conducted on 150 women aged 40 to 50 suffering from recurrent episodes of cystitis as attested by at least one positive urine culture during the six months preceding their recruitment.
METHODS: The subjects were randomly assigned to two groups: Group A: 100 women were given Kistinox® Forte, 1 sachet per day during the first 10 days of the month, for 3 months; Group B: 50 women did not receive any treatment to serve as a control group.
RESULTS: The results of the present study show a complete remission of urinary symptoms in 92 women; a slight decrease in urinary symptoms was observed in 5 subjects, whereas 3 women who stopped the treatment after the first cycle were considered drop-outs.
CONCLUSIONS: This multicenter clinical study revealed the excellent efficacy and tolerability of Kistinox® Forte sachets in the treatment and prevention of urinary disorders in peri- and postmenopausal women. The posology of a sachet a day during the first 10 days of the month for 3 months was well tolerated by the patients, who did not report any disorder arising from the product.


KEY WORDS: Postmenopause - Cystitis - Dysuria - Vaccinium macrocarpon - Mannose

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Publication History

Issue published online: June 8, 2017
Manuscript accepted: April 17, 2017
Manuscript received: April 11, 2017

Cite this article as

De Leo V, Cappelli V, Massaro MG, Tosti C, Morgante G. Valutazione degli effetti di un integratore naturale a base di cranberry, Noxamicina® e D-mannosio nelle infezioni urinarie recidivanti in donne in perimenopausa. Minerva Ginecol 2017;69:336-41. DOI: 10.23736/S0026-4784.17.04074-6

Corresponding author e-mail

vincenzo.deleo@unisi.it