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A Journal on Obstetrics and Gynecology

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Minerva Ginecologica 2016 August;68(4):431-49

language: English

Current tools for the optimization of embryo transfer technique for recurrent implantation failure

Frederic MITRI 1, Dan NAYOT 2-4, Robert F. CASPER 2-4, Yaakov BENTOV 2-4

1 Levant Clinic, Beirut, Lebanon; 2 Toronto Centre for Advanced Reproductive Technology, Toronto, ON, Canada; 3 Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada; 4 Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada


Recurrent implantation failure (RIF) is the name of a clinical condition coined following the widespread use of in-vitro fertilization (IVF), which has allowed compartmentalization of several different fertility treatments. Its definition is dynamic and depends on the population of patients studied, as well as the type and quality of clinical practice. In this review we survey the tools which are currently used in order to improve treatment outcome in patients with recurrent implantation failure. Some of these practices are more commonly or firmly established than others, however the beneficial contribution of most of these tools to improve reproductive outcomes among patients with recurrent implantation failure still lacks proper scientific validation.

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