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A Journal on Obstetrics and Gynecology

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Minerva Ginecologica 2014 December;66(6):527-33

language: Italian

Combination inositol and glucomannan in PCOS patients

De Leo V. 1, Tosti C. 1, Cappelli V. 1, Morgante G. 1, Cianci E. A. 2

1 Centro di Sterilità di Coppia, Dipartimento di Medicina Molecolare e dello Sviluppo, Università degli Studi di Siena, Siena, Italia;
2 Clinica Ostetrica e Ginecologica, Università degli Studi di Catania, Catania, Italia


AIM: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies of the reproductive age in women. PCOS is an endocrine-metabolic disorder characterized by insulin resistance. Aim of the study was to evaluate the efficacy of natural substances such as inositol and glucomannan, and their combination in reducing glucose levels and improving insulin sensitivity in PCOS patients.
METHODS: Forty women with clinical and endocrinological signs of PCOS were enrolled in the study and divided into three groups, including ten women each. The three groups were respectively treated with the combination inositol and glucomannan (A group), inositol (B group), glucomannan (C group) for a period of 3 months. Plasma levels of glucose and insulin were evaluated before and after treatment in our laboratory.
RESULTS: There was a reduction in blood glucose and insulin levels, with particular significance in the group treated with the combination of inositol-glucomannan.
CONCLUSION: Present results show that the association-inositol glucomannan may represent a good therapeutic strategy in the treatment of PCOS women with insulin resistance.

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