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A Journal on Obstetrics and Gynecology

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Minerva Ginecologica 2014 October;66(5):443-7

language: English

Prediction of large-for-gestation neonates with first-trimester maternal serum PAPP-A

Rossi A. 1, Vogrig E. 1, Ganzitti L. 1, Forzano L. 1, Simoncini G. 1, Romanello I. 1, Ambrosini G. 2, Marchesoni D. 1

1 Department of Obstetrics and Gynecology, University of Udine, Udine, Italy;
2 Department of Obstetrics and Gynecology, University of Padua, Padua, Italy


AIM: The aim of this paper was to identify maternal/pregnancy characteristics, first trimester ultrasound parameters and biochemical indices which are significant independent predictors of large-for-gestational age (LGA) neonates.
METHODS: An Observational cross-sectional study was conducted at the Fetal Medicine Unit, Department of Obstetrics and Gynecology of the University of Udine (Italy). Seventy-two singleton pregnancies presenting for screening for chromosomal abnormalities by nuchal translucency and maternal serum biochemistry at 11-14 weeks. Linear regression was applied to develop first trimester prediction models for LGA.
RESULTS: Maternal height, parity, smoking, assisted conception and pregnancy-associated plasma protein-A were significant independent predictors of LGA. PAPP-A cut-off value expressed in MoM of 1.25 used for the study was chosen to obtain good sensitivity and specificity values.
CONCLUSION: Prediction for birthweight deviations (LGA) is feasible using data available at the routine 11-14 weeks’ examination.

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