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A Journal on Obstetrics and Gynecology

Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index

Frequency: Bi-Monthly

ISSN 0026-4784

Online ISSN 1827-1650


Minerva Ginecologica 2012 June;64(3):245-51


Bacterial vaginosis prophylaxis with a vaginal device releasing chlorhexidine. Preliminary study

Anglana F. 1, Oliva C. 1, 2

1 Bios International, Roma, Italia;
2 Unità Operativa Complessa di Ginecologia e Ostetricia, A.C.O. San Filippo Neri, Roma, Italia

AIM: Assessment of clinical, microbiogical and subjective postmenstrual data relating to bacterial vaginosis in patients using a vaginal device releasing chlorhexidine.
METHODS:Twenty women with vaginosis signs and symptoms before menstruation were randomized to use vaginal tampons releasing chlorhexidine or neutral tampons (placebo). They were reassessed after menstruation.
RESULTS: After treatment there was improvement of symptoms referred, but not significant. Itching was particularly reduced after use of chlorhexidine tampon. Vaginal pH was reduced but not significantly in the treated group. Gram stain microscopy showed absence of normal vaginal microflora in all recruited patients. Frequency detection of Doderlein Lactobacilli and clue cells<20% at control time was significantly increased (70%) in patients exposed to the action of chlorhexidine when compared to placebo group (30%).
CONCLUSION: Therapy effectiveness is probably due to local anti-inflammatory and antiseptic chlorhexidine properties. Good patient compliance is an additional result in favor of the product. Data collected in this study are a preliminary result.

language: Italian


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