Home > Journals > Minerva Ginecologica > Past Issues > Minerva Ginecologica 2012 April;64(2) > Minerva Ginecologica 2012 April;64(2):89-94

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA GINECOLOGICA

A Journal on Obstetrics and Gynecology


Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index


eTOC

 

ORIGINAL ARTICLES  


Minerva Ginecologica 2012 April;64(2):89-94

language: Italian

Short-course treatment of vulvovaginal candidiasis: comparative study of fluconazole and intra-vaginal fenticonazole

Murina F. 1, Graziottin A. 2, Felice R. 1, Di Francesco S. 1, Mantegazza V. 1

1 Servizio di Patologia Vulvare, Ospedale Vittore Buzzi, Università di Milano, Milano, Italia;
2 Centro di Ginecologia, Ospedale San Raffaele Resnati, Milano, Italia


PDF  


AIM:The aim of this paper was to compare the efficacy of fluconazole 150 mg and intra-vaginal fenticonazole 600mg in short-course treatment of the acute episode of vulvovaginal candidiasis (VVC).
METHODS: In a prospective study, 80 patients with clinical and mycological (SavvyCheck™ test) confirmed VVC were enrolled and divided randomly in two groups. Forty patients received oral fluconazole (150 mg), whereas 40 patients received intra-vaginal tablet fenticonazole (600 mg). Two sequential doses of azole agents were given 3 days apart (short-course treatment). Second and third visits were done for all patients seven and 30±5 days after treatment.
RESULTS: At the second visit, 31 patients (77.5%) were cured clinically (Sobel score <4) in fluconazole group and 32 patients (80%) in fenticonazole group (P=0.876). The vulvovaginal pruritus was reduced in lower time in fenticonazole patients than in fluconazole group (mean 2.3 days versus 4.5 days, P=0.047). At the third visit, three patients in fluconazole group and two patients in fenticonazole group had clinical sign of VVC.
CONCLUSION: Fluconazole and intravaginal fenticonazole are both effective to cure symptoms of VVC but fenticonazole appears to reduce the pruritus in less time

top of page

Publication History

Cite this article as

Corresponding author e-mail

filippomurina@tin.it