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A Journal on Obstetrics and Gynecology

Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index

Frequency: Bi-Monthly

ISSN 0026-4784

Online ISSN 1827-1650


Minerva Ginecologica 2011 June;63(3):237-45


Psychic aspects of the premenstrual dysphoric disorders. New therapeutic strategies: our experience with Vitex agnus castus

Ciotta L. 1, Pagano I. 1, Stracquadanio M. 1, Di Leo S. 1, Andò A. 2, Formuso C. 1

1 Istituto di Patologia Ostetrica e Ginecologica, Università degli Studi di Catania, Catania, Italia;
2 Corso di Laurea Specialistica in Psicologia, Università degli Studi di Catania, Catania, Italia

AIM: The premenstrual dysphoric disorder (PMDD) is one of the main problems of the premenstrual phase. It consists of symptoms that sometimes invalidate the scope of employment, social and psycho-affective of patients, requiring thus a diagnostic and therapeutic approach as detailed and accurate as possible. The therapeutic strategies available for this disease are many, but recently the emphasis has been on Vitex agnus castus (VAC), considered by many as evidence drug of choice for both PMS and for the PMDD, being with satisfactory therapeutic properties and small side effects.
METHODS AND RESULTS: Our study evaluated a group of patients suffering from PMDD and the clinical efficacy of treatment with VAC (and compared the effectiveness of the results of a more homogeneous group of patients treated with fluoxetine).
CONCLUSION: This study confirms the data reported in the literature regarding the effectiveness of VAC therapy with no side effects.

language: Italian


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