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A Journal on Obstetrics and Gynecology

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Minerva Ginecologica 2010 December;62(6):525-31

language: Italian

Effects of inositol on oocyte quality in patients affected with polycystic ovary syndrome

Ciotta L., Stracquadanio M., Pagano I., Carbonaro A., Palumbo M., Gulino F.

Sezione di Ginecologia, Dipartimento di Scienze Microbiologiche e Scienze Ginecologiche, Ospedale Santo Bambino
Università degli Studi di Catania, Catania, Italia


AIM: Polycystic ovary syndrome is the most common cause of chronic anovulation infertility in women in fertile period. The supplementation of inositol, due to its ability to increase insulin sensitivity, improves the oocytes’ quality and increase the number of oocytes collected after ovarian stimulation in patients undergoing IVF (In Vitro Fertilization). The aim of our study is to determine the effects of myo-inositol on oocyte’s quality on a sample of women with polycystic ovary syndrome.
METHODS: The patients were divided into two groups: patients of Group A intook 2 g of myo-inositol + 400 μg of folic acid 2 times a day, continuously for 3 months, while Group B only 400 μg of folic acid.
RESULTS AND CONCLUSION: At the end of treatment, the number of follicles of diameter >15 mm, visible at ultrasound during stimulation, and the number of oocytes recovered at the time of pick-ups were found to be significantly greater in the group treated with myo-inositol, so as the average number of embryos transferred and embryo Grade G1. Significantly reduced was the average number of immature oocytes (vesicles germ and degenerated oocytes) too.

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