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A Journal on Obstetrics and Gynecology

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Minerva Ginecologica 2010 June;62(3):195-201

language: Italian

Efficacy study in vitro: assessment of the properties of resveratrol and resveratrol + N-acetyl-cisteine on proliferation and inhibition of collagen activity

Giardina S. 1, Michelotti A. 1, Zavattini G. 2, Finzi S. 3, Ghisalberti C. 4, Marzatico F. 5

1 Farcoderm srl, San Martino Siccomario, Pavia, Italia;
2 MarvecsPharma, Milano, Italia;
3 Vitrupharma Srl, Milano, Italia;
4 R & D in Skin and Mucosal Disorders, Milano, Italia;
5 Laboratorio di Farmacobiochimica, Sezione di Scienze Farmacologiche e Tossicologiche Università di Pavia, Pavia, Italia


During and after menopause the skin shows up clearly how the lack of estrogen affects tissues, and menopause can in fact be considered a “multisystemic” disorder of connective tissue. The low menopausal estrogen levels combined with age-related skin changes, accelerating skin aging. This affects both the epidermis and the dermis: fibroblasts not only become fewer, but they produce 30% less collagen, reflecting its metabolic decline. Estrogens act on collagen synthesis by directly stimulating fibroblasts. However, hormone replacement can prevent the postmenopausal loss of collagen – or eliminate it once it has started. The results of the Women’s Health Initiative study drastically changed Italian gynecologists’ prescribing habits. Natural products with estrogen-like activity are increasingly accepted, since they have good effects on collagen synthesis and/or inhibit collagenase activity, with a reassuring safety profile. This was confirmed by an in vitro study that assessed the tonic-trophic properties of two treatments on cultured skin fibroblasts. Cells were treated with resveratrol either alone or combined with NAC 10-100-1000 µM. There was a dose-related increase in the rate of cell proliferation and in inhibition of collagenase activity.

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