Home > Journals > Minerva Ginecologica > Past Issues > Minerva Ginecologica 2009 October;61(5) > Minerva Ginecologica 2009 October;61(5):459-54

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA GINECOLOGICA

A Journal on Obstetrics and Gynecology


Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index


eTOC

 

TECHNICAL NOTES  


Minerva Ginecologica 2009 October;61(5):459-54

language: Italian

Nomegestrol acetate: clinical pharmacology

Lello S.

Dipartimento di Ginecologia Endocrinologica, Fisiopatologia della Menopausa e Osteoporosi, IDI-IRCCS, Roma, Italia


PDF  


Progestogens are used in clinical practice in some conditions. Their effects depend on their chemical structure, pharmacokinetics, pharmacodynamics, with important differences among various progestogens. Generally, progestins are classified according to their parent molecule, of which often they keep some features. Derivatives of 19-nor-progesterone are characterized by high selectivity of action on progestin receptor. In particular, nomegestrol acetate (NomAc) shows an important progestational potency, neutral gluco-lipid profile, and antigonadotropic activity. It is used for treating menstrual cycle disorders and for hormone replacement therapy in menopause in association with an estrogen. In future, thanks to its antigonadotropic activity, NomAc will be used in estroprogestin combinations in fertile women, thus taking advantage of its tolerability profile and obtaining numerous non-contraceptive benefits as well.

top of page

Publication History

Cite this article as

Corresponding author e-mail