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Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index
Online ISSN 1827-1650
REPRODUCTIVE MEDICINE: A BRIDGE TO THE FUTURE
Oktem O. 1, Oktay K. 2
1 Women’s Health Center, Assisted Reproduction Unit Molecular Reproduction and Fertility Preservation Program, American Hospital, Istanbul, Turkey
2 Institute for Fertility Preservation, Department of Obstetrics and Gynecology, Westchester Medical Center-New York Medical College Valhalla, NY, USA
For decades it has remained as a central dogma in dogma in reproductive biology that female mammals are born with a set non-renewable number of germ cells in the ovary. Recent revolutionary studies challenged this dogma by showing postnatal oogenesis in the adult ovary. In this review article the formation of primordial germ cells (PGC), the precursors of adult gametocytes beginning from their specification to their migration to prospective gonads will be reviewed with a special emphasis on stem cells studies that obtained gametocytes from germ and non germline stem cells.