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A Journal on Obstetrics and Gynecology
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index
Minerva Ginecologica 2008 August;60(4):273-9
Preoperative platelet count as index of the grading in the endometrial carcinoma
Giannella L. 1, Menozzi G. 1, Di Monte I. 2, Venturini P. 2, De Pace V. 2, Boselli F. 2, Termelli G. 1, Jasonni V. M. 2
1 Divisione di Ostetricia e Ginecologia, Ospedale “C. Magati” di Scandiano, Reggio Emilia, Italia
2 Dipartimento Materno-Infantile, Istituto di Ginecologia e Ostetricia, Università degli Studi di Modena e Reggio Emilia, Modena, Italia
Aim. To investigate a possible relationship between preoperative platelet count and following clinicopathological variables of the endometrial carcinoma: age, stage, histological type, histological grading (G), myometrial invasion, lymphovascular space involvement, cervical involvement, lymph node metastasis. In particular the existence of a possible relationship between elevated preoperative platelet count (≥300 000 µL) and negative prognostic factors.
Methods. The authors analyzed retrospectively 120 patients with endometrial carcinoma underwent to surgery as the initial treatment. All the patients were subjected to radical surgical procedure: peritoneal cytology, total abdominal hysterectomy, bilateral salpingo-oophorectomy, systematic pelvic lymphadenectomy and omentectomy. Blood platelet count was taken from the patients three days prior to the surgery.
Results. The patients with platelet count <300000/ µL whom they had a G1, G2, G3 they were respectively the 23.1%, 44.2% and 32.7 % versus the 0%, 12.5% and 87.5%, respectively for G1, G2, G3, of the patients with platelet count >300000/µL (P=0.024). Only considering the patients to the stage I of the Federazione Internazionale dei Ginecologi ed Ostetrici (FIGO). The patients with platelet count <300000/ µL whom they had a G1, G2, G3 they were respectively the 27.3%, 43.2% and 29.5% versus the 0%, 0% and 100%, respectively for G1, G2, G3, of the patients with platelet count ≥300000/µL (P=0.008). There were no differences respect to age, stage, histological type, myometrial invasion, lymphovascular space involvement and cervical involvement.
Conclusion. Elevated preoperative platelet count, in the patients with endometrial carcinoma, may reflect poor prognostic factor such as higher histological grade. This study allowed to observe: a significant correlation between elevated preoperative platelet count (≥300000/µL) and tumoral grading (G3) of general population submitted to study; for the patients to the stage I FIGO a more significant correlation between elevated preoperative platelet count (≥300000/µL) and tumoral grading: the 100% of the patients with platelet count ≥300 000/µL had a histological grading G3.