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Minerva Ginecologica 2008 June;60(3):239-43

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: Italian

Effect on skin and hormonal hyperandrogenic manifestations of an oral estroprogestin association containing Ethynilestradiol 30 µg and Drospirenone 3 mg

Lello S. 1, 2, Primavera G. 3, Colonna L. 3, Vittori G. 2, Guardianelli F. 2, Pallotta P. 3, Sorge R. 4, Bilchugova E. 3, Raskovic D. 3

1 Servizio di Ginecologia Endocrinologica e Fisiopatologia della Menopausa, IRCCS - Istituto Dermopatico dell’Immacolata Roma, Italia 2 Divisione di Ginecologia, IRCCS-Istituto Dermopatico dell’Immacolata Ospedale San Carlo, Roma, Italia 3 Servizio di Dermocosmetologia e Fisiopatologia Cutanea, IRCCS- Istituto Dermopatico dell’Immacolata Roma, Italia 4 Laboratorio di Biometria, Università di Tor Vergata, Roma, Italia


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Aim. This study evaluated hormonal and skin effects in hyperandrogenic women of an oral estroprogestin (EP) association containing ethynilestradiol 30 mcg plus drospirenone 3 mg.
Methods. Thirty two women with signs and symptoms of hyperandrogenism (seborrhea, acne, increased hair); hormonal assessment (follicle-stimulating hormone, [FSH]; luteinizing hormone, LH; 17-hydroxi-progesterone, 17OHP; androstenedione, A, testosterone, T; dehydroepiandrosterone sulfate, DHEAS; sex hormone binding globulin, [SHBG]; Free Androgen Index [FAI, T×100/SHBG] was performed before the start of treatment, and after 3 and 6 months of administration of EP. The impact on seborrhea, acne, and hair pattern (Ferriman-Gallwey score) was assessed, and, by non-invasive technique, hydration, water transpiration, and homogeneity of the skin were evaluated.
Results. Treatment with this EP for 6 months decreased significantly circulating androgen levels (A, T, DHEAS) and FAI, and increased SHBG levels, also reducing seborrhea, acne and hirsutism. Moreover, EE/DRSP increased hydration and improved overall appearance of skin surface (homogeneity).
Conclusion. Treatment with EE 30 mcg+DRSP 3 mg improves hormonal pattern and skin appearance in hyperandrogenic patients, potentially with subsequent, beneficial effects on quality of life of these women.

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