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A Journal on Obstetrics and Gynecology

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Minerva Ginecologica 2008 April;60(2):127-33

language: Italian

“Prepidil versus Propess”: pharmacological induction of labour with dinoprostone

Arduini M. 1, Giri C. 1, Giannone L. 2, Giannone E. 1

1 Scuola di Specializzazione in Ginecologia e Ostetricia, Dipartimento di Specialità Medico Chirurgiche e Salute Pubblica, Università degli Studi di Perugia, Perugia, Italia
2 Struttura complessa di Ostetricia e Ginecologia, Azienda Ospedaliera di Arezzo, Arezzo, Italia


Aim. The aim of the study was to evaluate the effectiveness and safety of the two different pharmaceutical preparations of dinoprostone: “Prepidil vs Propess”, in patients with medical and/or obstetrical indications to pharmaceutical induction of labour.
Methods. A retrospective analysis was carried out on 144 patients (82 with Propess vs 62 with Prepidil). Indications: post-term pregnancy, premature rupture of membranes (PROM), gestational diabetes, gestational-chronic hypertension, intrauterine growth restriction (IUGR),others (fetal macrosomia, oligohydramnios).
Results. The groups were homogenous regarding: age, parity, weeks of amenorrhea, Bishop score and indication to induction. Both pharmaceutical preparations of dinoprostone (Prepidil vs Propess) are effective and safe; there are some differences not statistically significant (P>0.01) regarding the percentage of spontaneous deliveries: 61.5% vs 63%, interval from induction to delivery 24.53 vs 20.45 h, number of inductions 1.35 vs 1.15 and neonatal outcome (Apgar scores at 1 and 5 min). A case of serious hyperstimulation with hysterectomy post-delivery after induction with Prepidi was observed.
Conclusion. A greater use of Propess, especially in patients with PROM, is suggested; Propess has determined a higher percentage of spontaneous deliveries, a shorter interval from induction to delivery and less risks for the mother. It is in fact possible to remove the device easily and safely in case of complication.

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