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A Journal on Obstetrics and Gynecology

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Minerva Ginecologica 2007 June;59(3):215-22

language: Italian

Evaluation of the hematochemical parameters and bone mineral density in women in physiological menopause treated with hormone replacement therapy with acetate nomegestrol and surgical menopause treated with estrogen replacement therapy. Part II

Savoca S., D’Agosta S., Lombardo G.

Unità per gli Studi sulla Menopausa, Clinica Ostetrica e Ginecologica II, Dipartimento di Ostetricia, Ginecologia e Scienze Radiologiche, Azienda Ospedaliero-Universitaria
“Gaspare Rodolico”, Policlinico di Catania, Catania, Italia


Aim. The purpose of this paper was to estimate the effectiveness of the use of acetate nomegestrol in relation to indicator haematochemicals and bone mineral density (BMD) regarding patients in physiological menopause treated with hormone replacement therapy (HRT), compared to patients in surgical menopause treated with HRT by only administering transdermally hemi hydrate estradiol (estrogen replacement therapy, ERT).
Methods. Sixty women in menopause for at least 6 months ago, aged between 40 and 55 years, were recruited. Thirty of them were given HRT with acetate nomegestrol, and 30 were given only ERT, because they were subjected to general hysterectomy with bilateral adnexectomy. The standards for inclusion were: level of FSH ≥ to 30 UI β-estradiol Results. Both groups at the end of treatment showed an increase in BMD level, whereas haematochemical tests were regular or at least stabilized in a large percentage of patients.
Conclusion. This research has shown the validity of HRT on BMD, underlining a more noteworthy improvement in the patients’ group that used acetate nomegestrol than in those that only used estrogens.

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