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A Journal on Obstetrics and Gynecology

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Minerva Ginecologica 2006 June;58(3):249-54

language: Italian

Sensitivity, specificity, predictive positive and negative value of the main clinical signs and symptoms of hydatiform mole

Indraccolo U., Giannone L., Canonico S., Giannone E.

1 Dipartimento di Specialità Chirurgica e Salute Pubblica Scuola di Specializzazione in Ginecologia e Ostetricia Università degli Studi di Perugia, Perugia
2 Struttura Complessa di Ostetricia e Ginecologia Azienda Ospedaliera di Arezzo, Arezzo


Aim. Especially in the first weeks of pregnancy, complete and partial hydatiform moles are not easily detected by sonography, symptoms and clinical signs. Due to the rarity of moles, it is possible that they may be confused with abortive pregnancies until the pathological examination. The aim of this study is to identify the sensitivity, specificity, predictive positive and negative value of the main symptoms and clinical signs of molar pregnancies.
Methods. Thirteen molar pregnancies have been detected after pathological examination from January 2003 to July 2005 in Perugia. Their main clinical signs and symptoms are compared with those recorded in 288 abortive pregnancies, 56 ectopic pregnancies and 27 Hyperemesis gravidarum, observed in the same period.
Results. Vaginal bleeding and pelvic pain are the most sensitive symptoms and have the highest predictive negative values. The size of the uterus greater for date is the most specific sign. Pelvic pain with hyperemesis, and uterus size greater for date have the highest predictive positive values, but the lowest sensitivity.
Conclusion. A mole should be excluded in patients with hyperemesis and pelvic pain, and in patients with uterus size greater for date. In the first case, an hyperemesis gravidarum may be diagnosed and, in the second one, a twin pregnancy may be confirmed with a sonographic scan.

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