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A Journal on Obstetrics and Gynecology
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index
REVIEWS CLINICAL ADVANCES IN CONTRACEPTION
Minerva Ginecologica 2006 June;58(3):209-14
Oral contraceptives and cancer
La Vecchia C.
1 Istituto di Ricerche Farmacologiche Mario Negri, Milano
2 Istituto di Statistica Medica e Biometria Università degli Studi di Milano, Milano
Oral contraceptives (OC) convey a protection against ovarian, endometrial and perhaps colorectal cancer. However, OC use is associated with excess risk of breast (current or recent use only), cervical and liver cancer. Benefits and risks of OC use on cancer were reviewed in 2005 by a Working Group at the International Agency for Research on Cancer, which concluded that combined OCs are carcinogenic to humans, based on an increased risk for hepatocellular carcinoma, cervical and (for current use only) breast cancers. The Working Group also concluded that there is conclusive evidence that OCs have a protective effect against cancers of the ovary and endometrium.