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Minerva Ginecologica 2005 October;57(5):557-62

Copyright © 2005 EDIZIONI MINERVA MEDICA

language: Italian

The significance of screening tests for aneuploidies in populations at low and high maternal-age-related risk

Centini G., Rosignoli L., Scarinci R., Pasqui L., Talluri B., Kenanidis A., Faldini E., Cazzavacca R., Petraglia F.


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Aim. The aim of this study was to evaluate the validity of the triple test and the screen test in maternal populations at low and high maternal-age-related risk for fetal aneuploidy.
Methods. As a whole, 9 680 pregnant women at low risk and 627 at high risk underwent the triple test; 2 780 pregnant women at low risk and 408 at high risk underwent the screen or combined test; sensitivity, specificity, false positives and detection rate were compared between populations using Student's t-test.
Results. The triple test showed a detection rate of 75% in the low and 83.3% in the high risk population with a difference (P<0.003) for detection of trisomies 21 and 18 between the 2 populations; the screen test had a detection rates of 100% and 90% in the 2 populations, respectively, with a difference (P<0.005) between the 2 tests.
Conclusion. Both tests are reliable for screening aneuploidies in the low risk population, the screen test having better performance; in the high risk population, the number of invasive procedures can be reduced by 78% with the triple test and by 84% with the screen test.

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