Advanced Search

Home > Journals > Minerva Ginecologica > Past Issues > Minerva Ginecologica 2005 February;57(1) > Minerva Ginecologica 2005 February;57(1):87-98

ISSUES AND ARTICLES   MOST READ   eTOC

CURRENT ISSUEMINERVA GINECOLOGICA

A Journal on Obstetrics and Gynecology

Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index

Frequency: Bi-Monthly

ISSN 0026-4784

Online ISSN 1827-1650

 

Minerva Ginecologica 2005 February;57(1):87-98

HUMAN REPRODUCTION 

The impact of altered insulin-like growth factor-I secretion on the neuroendocrine and testicular functions

Chandrashekar V., Bartke A.

There is unequivocal evidence that the biosynthesis and secretion of gonadotropins by the pituitary gland is controlled by the hypothalamic GnRH and the function of the testis is mainly regulated by FSH and LH. However, a number of investigations have suggested the role of other hormones/factors, including insulin-like growth factor-I (IGF-I) in the control of pituitary and gonadal functions. The role of growth hormone (GH) and IGF-I is poorly investigated in humans. In animals with altered IGF-I secretion, the gonadotropin and androgen secretions are affected. Similarly, there is evidence that fertility, the onset of puberty and sexual maturation are affected in some patients with Laron syndrome and in acromegaly. In this minireview, we have presented some data obtained in humans and also included results from several experimental models with altered GH/IGF-I secretion, in the hope that the results from animals will possibly help in understanding the important role of IGF-I in the control of neuroendocrine-testicular function in humans.

language: English


FULL TEXT  REPRINTS

top of page