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A Journal on Obstetrics and Gynecology
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index
Minerva Ginecologica 2004 February;56(1):91-104
Biologic therapy and epithelial ovarian cancer
Porpiglia M., Vicelli R., Durando A., Fracchioli S., Puopolo M., Katsaros D., Bellino R., Benedetto C.
The identification of new molecular prognostic and predictive factors for ovarian cancer may contribute in deciding individual therapeutic strategies; on the other hand, there has been growing interest in new biologic therapies to correct molecular or genic lesions of neoplastic cells (genic therapy), or to activate the specific immune response (immunological therapy). Chemotherapy collateral toxic effects, as myelotoxicity, should be reduced through transfection of genes that modulate drug resistance in stem cells. The data at present available suggest then the potential role of these new treatments, are more specific and less toxic than current therapies; hovewer, other biological-molecular studies are required to obtain the clinical applications of the results. Aim of this study is to provide a review of the most interesting data in ovarian cancer biologic therapy.