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A Journal on Obstetrics and Gynecology

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Minerva Ginecologica 2003 June;55(3):271-4

language: Italian

Severe form of pemphigoid gestationis

Orsini G, Loizzi P., Morelli L., Chiechi L. M., Sabatini R., Distante G.


We report a very severe form of hepers gestationis that arose at the 26th week of pregnancy and reached us for observation at the 30th week. Herpes gestationis in an autoimmune vesicobullous dermatosis characterised by skin eruptions, intense itching and consequent increase in fetal morbility, with delayed intrauterine growth and prematurity. Owing to its particular severity (involvement of the entire body surface including the face), between the 30th and the 32nd weeks we had to address a severe clinical condition characterised by anaemia, marked hypoproteinaemia, hypoalbuminaemia, hupertension and hyperglycaemia which led us to resort to the maximum dose of oral corticotherapy in association with topical therapy using clobetasol propionate. In our opinion the results obtained were highly statisfactory with the result that at the ednd of the 37th week, in consideration of the patient's obstetric history, podalic presentation and parity, we performed a Caesarean delivering a newborn of 3000 g in excellent condition. The patient was discharged symptom-free on the 6th day and the newborn was in full healt.

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