Home > Journals > Minerva Ginecologica > Past Issues > Minerva Ginecologica 2002 February;54(1) > Minerva Ginecologica 2002 February;54(1):9-14

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

MINERVA GINECOLOGICA

A Journal on Obstetrics and Gynecology


Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index


eTOC

 

ORIGINAL ARTICLES  


Minerva Ginecologica 2002 February;54(1):9-14

language: Italian

Genetic mutations, acquired disorders and obstetric pathology. Personal experience

Arcadia P., Cosco A. G., Ierullo A. M., Palomba S., Guarany R., Muleo G., Santoro R., Zullo F.


PDF  


Background. To evaluate the incidence of thrombophilic disorders such as Factor II mutation, Leiden factor V and MTHFR genotype, and anti-phosholipid anti-bodies syndrome in women with or without pregnancy related problems.
Methods. Sixty-three patients (group A) with pregnancy complications were included in the study and tested for Factor V mutation, Factor II mutation, 5-10 MTHFR reductase mutation and anti-phospholipid antibodies syndrome. The incidence of disorders was compared with thirty-six pregnancies without complications (control study, group B).
Results. Hemostasis thrombophilic like disorders, were significantly high (p=0.001 vs group B). Nobody in both groups was homozigous for Leiden mutation or prothrombin mutation (Factor II). The prevalence of Factor V mutation in heterozygosis was significantly (p=0.01) higher in group A in comparison with group B. The MTHFR mutation in homozygosis was found in 21.4% of group A while in the control group it was 11%. Factor II mutation in heterozygosis and anti-phospholipid antibodies were found only in group A.
Conclusions. It is important to evaluate the hemocoaugulation patterns in women with a history of complicated pregnancies.

top of page

Publication History

Cite this article as

Corresponding author e-mail