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A Journal on Obstetrics and Gynecology
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index
Minerva Ginecologica 2000 December;52(12):521-6
Endometrial carcinoma during tamoxifen therapy. A case report
Valenzano Menada M., Corticelli A., Giannesi A., Nicoletti L., Podestà M., Rissone R., Fulcheri E.
Tamoxifen is a non-steroid estrogenic antagonist, used in post-surgical therapy of breast cancer. It interferes with endocrinous promotion of breast cancer. Tamoxifen could determine endometrial, even carcinomatous, alterations.
The case of a postmenopausal patient surgically treated for breast cancer and successively treated with tamoxifen (20 mg/die), is reported.
She underwent ultrasonographic and hysterosonographic endometrial evaluation and finally a hysterectomy with bilateral annessiectomy.
This case seems to confirm tamoxifen possible carcinogenical effects on the endometrium.