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A Journal on Endocrine System Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,118
Minerva Endocrinologica 2017 Feb 15
Copyright © 2017 EDIZIONI MINERVA MEDICA
Laparoscopic roux-en-y gastric bypass vs. laparoscopic sleeve gastrectomy for morbid obesity: a systematic review and meta-analysis of lipid effects at one year post-surgery
Elisenda CLIMENT 1, 2, David BENAIGES 1-3 ✉, Juan PEDRO-BOTET 1, 2, 3, Albert GODAY 1-4, Ivan SOLÀ 5, 6, José M. RAMÓN 3, 7, Juana A. FLORES-LE ROUX 1, 2, 3, Miguel Á. CHECA 8, 9, 10
1 Department of Endocrinology and Nutrition, Hospital del Mar, Paseo Marítimo, Barcelona, Spain; 2 Department of Medicine, Universitat Autònoma de Barcelona, Campus Universitari Mar, Barcelona, Spain; 3 Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain; 4 CiberOBN, Instituto de Salud Carlos III, Madrid, Spain; 5 Iberoamerican Cochrane Centre, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain; 6 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; 7 Department of General Surgery, Hospital del Mar, Barcelona, Spain; 8 Department of Obstetrics and Gynaecology, Hospital del Mar, Barcelona, Spain; 9 Department of Paediatrics, Obstetrics and Gynaecology and Public Health, Universitat Autònoma de Barcelona, Barcelona, Spain; 10 Grup de Recerca en Infertilitat de Barcelona (GRI-BCN), (SGR527), Barcelona, Spain
INTRODUCTION: Results of the effects of Roux-en-Y gastric bypass (GB) and sleeve gastrectomy (SG) on triglyceride and high-density lipoprotein (HDL) cholesterol levels are controversial. Moreover, previous meta-analyses focused on global dyslipidaemia remission, but did not include the separate remission rates of the different lipid fractions. Hence, the aim of the present meta-analysis was to compare the outcomes (concentration change and remission rates) of GB and SG on diverse lipid disorders one year post-bariatric surgery (BS).
EVIDENCE ACQUISITION: An exhaustive electronic search carried out on MEDLINE, EMBASE and The Cochrane Central Register of Controlled Trials (CENTRAL) until July 2016 yielded 2621 records, of which 17, totalling 4,699 obese patients with one-year follow up after BS were included in the meta-analysis.
EVIDENCE SYNTHESIS: GB was superior to SG in terms of total cholesterol (mean difference= 19.77 mg/dl, 95% CI= 11.84 to 27.69) and low-density lipoprotein (LDL) cholesterol (mean difference: 19.29 mg/dl, 95% CI: 11.93 to 26.64) decreases as well as in hypercholesterolaemia remission (RR: 1.43, 95% CI: 1.27 to 1.61). No differences were found between GB and SG in terms of HDL cholesterol increase or triglyceride concentration change after surgery, as well as in hypertriglyceridaemia and low HDL remission rates.
CONCLUSIONS: The effect of GB on total and LDL cholesterol concentration decreases and remission was greater than that of SG, whereas no differences were observed with respect to HDL cholesterol and triglyceride concentration evolution. Conclusions cannot be drawn from hypertriglyceridaemia and low HDL remission rates based on this meta-analysis.
KEY WORDS: Bariatric surgery - Morbid obesity – Triglycerides - HDL cholesterol - LDL cholesterol