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Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,118
Mercè FERNÁNDEZ-MIRÓ 1, 2, Juan J. CHILLARÓN 2, 3, 4, Mercè ALBAREDA 5, Sara FONTSERÈ 2, 6, Cristina COLOM 1, Lluís VILA 5, Juan PEDRO-BOTET 2, 3, 4, Juana A. FLORES LE-ROUX 2, 3, 4, on behalf of TEST-T1D study group
1 Department of Internal Medicine-Endocrinology and Nutrition, Centre d´Atenció Integral Dos de Maig, Barcelona, Spain; 2 Departament de Medicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain; 3 Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, Spain; 4 IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; 5 Department of Endocrinology and Nutrition, Hospital de Sant Joan Despí Moisès Broggi, Sant Joan Despí, Spain; 6 Departament de Medicina, Universitat Pompeu Fabra, Barcelona, Spain
BACKGROUND: The hypertriglyceridemic waist has been linked to a higher number of cardiovascular risk factors and a greater probability of developing diabetes and cardiovascular disease. Around 50% of individuals with type 1 diabetes (T1D) are overweight or obese and triglyceridemia is associated with the onset of micro- and macrovascular complications.
METHODS: A cross-sectional study was conducted in men with T1D to assess the association between the prevalence of hypertriglyceridemic waist and cardiovascular risk factors and hypogonadism. Triglyceride levels + abdominal circumference taken together was stratified into quartiles to identify the hypertriglyceridemic waist phenotype.
RESULTS: One hundred and eighty-one male patients were included. An increased prevalence of hypogonadism and hypertension in parallel to increased triglyceride + waist circumference quartile was observed. Patients in the highest quartile had higher insulin resistance measured by estimated glucose disposal rate (eGDR 7.8 ± 2.1 mg/Kg- 1.min-1 in 1st quartile vs 5.8 ± 1.8 mg/Kg-1.min-1 in 4th quartile, p= 0.000), insulin requirements, hip circumference, percentage of fat mass, glycosilated hemoglobin and total and LDL cholesterol as well as lower levels of total testosterone (27.24 ± 9.3 nmol/L in 1st quartile vs 17.4 ± 8 nmol/L in 4th quartile, p= 0.000) and HDL cholesterol. An inverse relationship was found between triglycerides + waist circumference and total testosterone levels (R=-0.367, p< 0.0001).
CONCLUSIONS: The hypertriglyceridemic waist in men with T1D is associated with an atherogenic lipid profile, hypertension, worse metabolic diabetes control, increased insulin resistance and a higher prevalence of hypogonadism.