Total amount: € 0,00
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,118
Online ISSN 1827-1634
Marta KIAŁKA 1, Tomasz MILEWICZ 1, Sandra MROZIŃSKA 2, Iwona ROGATKO 3, Krystyna SZTEFKO 3, Renata MAJEWSKA 4
1 Department of Gynecological Endocrinology, Jagiellonian University, Medical College, Cracow, Poland; 2 Department of Metabolic Diseases, Jagiellonian University, Medical College, Cracow, Poland; 3 Department of Clinical Biochemistry, Jagiellonian University, Medical College, Cracow, Poland; 4 Department of Epidemiology, Chair of Epidemiology and Preventive Medicine, Jagiellonian University, Medical College, Cracow, Poland
BACKGROUND: Despite some evidence that indicates that the evolution of PCOS is related to the activity of the endogenous opioid system, and that concentration of plasma β-endorphin levels can increase pain threshold, there are no studies which evaluate pressure pain threshold in the PCOS women population.
METHODS: In 48 lean women with PCOS and 38 lean women without this disorder plasma β-endorphins and PPT were measured.
RESULTS: The β-endorphins level was higher in the PCOS group compared to the controls (15.28 ±2.49 pg/ml vs 6.33± 1.71 pg/ml, p <0.001). In PCOS group PPTs measured on deltoid and trapezius muscles were higher compared to the controls ( 9.33 ± 1.3 kg/cm2 vs 5.19 ± 0.57 kg/cm2, p <0.001; 8.23 ±1.04 kg/cm2 vs 4.79 ± 0.55 kg/cm2, p< 0.001). The β-endorphin levels positively correlated with PPTs in PCOS group. Increase in β-endorphin level of 1 pg/ml was associated with increase of PPT value on deltoid muscle of 0.23 kg/cm2 (R= 0.632, p=0.011) and of 0.18 kg/cm2 on trapezius muscle (R= 0.588, p =0.037). There were no correlations between testosterone level and PPT in PCOS group.
CONCLUSIONS: β-endorphin serum level as well as PPT are higher in lean PCOS group than in controls. We found correlations between β-endorphin levels and PPT in the PCOS group. It may suggest the role of endogenous opioids in the pathogenesis of PCOS and also that the increases in circulating plasma β-endorphins concentration can increases PPT in this group.