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A Journal on Endocrine System Diseases

Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,118

Frequency: Quarterly

ISSN 0391-1977

Online ISSN 1827-1634


Minerva Endocrinologica 2015 May 26

The relationship between phthalates and obesity: serum and urinary concentrations of phthalates

Oktar S. 1, 2, Sungur S. 3, Okur R. 3, Yilmaz N. 4, Ustun I. 5, Gokce C. 5

1 Department of Pharmacology, Medical Faculty of Mevlana University, Konya, Turkey;
2 Department of Pharmacology, Medical Faculty of Mustafa Kemal University, Hatay, Turkey;
3 Department of Chemistry, Mustafa Kemal University, Faculty of Arts and Sciences, Hatay, Turkey;
4 Department of Biochemistry, Medical Faculty of Mugla Sitki Kocman University, Mugla, Turkey;
5 Division of Endocrinology and Metabolism, Medical Faculty of Mustafa Kemal University, Hatay, Turkey

AIM: A limited number of human and animal studies suggest that a relationship exists between phthalates and obesity, although this is not supported by all research. The purpose of this study was to investigate the relationship between body mass index (BMI) and the levels of phthalates in human blood and urine samples.
METHODS: Sixty-four overweight or 132 obese individuals (total 196) of different ages (minmax, 17-62; mean ± SD, 42.07±11.3) and genders (f/m, 97/99) enrolled in the study. BMI and waist circumference were measured to diagnose obesity. Venous blood samples were taken after overnight fasting. To compare the urine phthalates among participants, single spot urine (at least 10 mL) was collected from the subject after blood samples were taken. Urine and blood phthalate concentrations were measured using gas chromatography.
RESULTS: Total blood/urinary phthalate levels significantly increased in proportion to the degree of obesity. There was a high correlation between the level of total phthalates in serum and BMI (correlation coefficient = 0.697, p <0.001), and between total urinary phthalate levels and BMI (correlation = 0.707, p <0.001).
CONCLUSION: This is the first study to have shown that both blood and urinary phthalates increased in proportion to BMI. The results show a strong association between obesity and phthalates.

language: English


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