Advanced Search

Home > Journals > Minerva Endocrinologica > Past Issues > Articles online first > Minerva Endocrinologica 2015 Feb 27

ISSUES AND ARTICLES   MOST READ   eTOC

CURRENT ISSUEMINERVA ENDOCRINOLOGICA

A Journal on Endocrine System Diseases

Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,118

Frequency: Quarterly

ISSN 0391-1977

Online ISSN 1827-1634

 

Minerva Endocrinologica 2015 Feb 27

Lithogenic factors in postmenopausal women with osteoporotic fracture

Ochoa-­Hortal Rull M. A. 1, Cano-­García M. 2, Arrabal-­Martín M. 3, Arrabal-­Polo M. A. 2

1 Traumatology department. Hospital Rafael Mendez. Lorca. Murcia, Spain;
2 Urology department. Hospital La Inmaculada. Huercal-­Overa, Spain;
3 Urology department. Granada University Hospital. IBS Granada. Granada, Spain

AIM: The aim of this study is to show the presence of phosphorus and calcium metabolism disorders and the presence of urine lithogenic factors in women with osteoporotic fracture without previous urinary lithiasis.
METHODS: We conducted a cross-­sectional study including 55 women with osteoporotic fracture surgically treated in the Trauma Department. We included women with osteoporotic fracture demonstrated by the fracture area, fracture mechanism and the presence of osteoporosis by bone densitometry. We analyzed ph ospho-­calcium metabolism as well as the calciuria, o xaluria, citraturia and uricosuria levels with fasting and 24-­hour urine study. The presence of abnormal calcium and phosphorus metabolism was compared between women with hypercalciuria and normocalciuria.
RESULTS: The 55 women had a mean age of 70.1 ± 13.8 years and a mean body mass index of 27.9 ± 3.8 kg/m2 . Forty-­percent of the patients showed hypercalciuria, 36.4% hyperoxaluria, 36.4% hypocitraturia, and 5.3% hyperuricosuria. When comparing patients with hypercalciuria and normocalciuria, the only statistically significant difference was fasting urinary calcium/creatinine levels (0.16 versus 0.08, respectively; p<0.0001).
CONCLUSION: Women with osteoporotic fracture showed several lithogenic factors in the urine studies, mainly fasting hypercalciuria. Although in this study, hypercalciuria did not involve the presence of lithiasis, it can favor the appearance of lithiasis with other predisposing conditions. Therefore, an accurate assessment of urine calcium levels with other lithogenic factors such as citrate and oxalate levels, may facilitate individualized management and treatment of osteoporosis without increasing the risk of nephrolithiasis.

language: English


FULL TEXT  REPRINTS

top of page