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MINERVA ENDOCRINOLOGICA

A Journal on Endocrine System Diseases


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Minerva Endocrinologica 2017 September;42(3):271-9

DOI: 10.23736/S0391-1977.16.02477-9

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

The possible impact of advanced glycation end products on pregnancy outcome in women with diabetes mellitus type 1

Magdalena, PERTYNSKA-MARCZEWSKA 1 , Katarzyna CYPRYK 2

1 Private Practitioner, New Malden, UK; 2 Diabetology and Metabolic Diseases Department, Medical University of Lodz, Lodz, Poland


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Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrate metabolism in which glucose is underutilized, resulting in hyperglycemia. Reproductive impairment in poorly controlled diabetes mellitus type 1 (T1DM) results from a combined effect of insulin deficiency and hyperglycemia that disrupt the functioning of metabolic signals participating in the regulation of the reproductive system. Good metabolic control as a result of intensive insulin therapy has a great impact on the fertility and childbearing possibilities in the T1DM females. Advanced glycation end products (AGEs) are formed by nonenzymatic modification of proteins, lipids, and nucleic acids by glucose. The formation and accumulation of AGEs are known to progress at an accelerated rate in diabetes. AGEs either act on the pro-inflammatory cell surface receptors called RAGE or bind to the circulating anti-inflammatory sRAGE that prevents activation of cell-surface RAGE by AGEs and other proinflammatory ligands. Pregnancy has been found to induce a significant increase in RAGE protein levels in both myometrium and omental vasculature. This review will focus on the role of AGEs and RAGE in pregnancy complicated by DM type 1 as well as ways to reduce the rate of congenital malformations in the offspring of diabetic type 1 women.


KEY WORDS: Hyperglycemia - Pregnancy outcome - Congenital abnormalities

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Publication History

Issue published online: June 12, 2017
Article first published online: June 15, 2016
Manuscript accepted: June 7, 2016
Manuscript revised: May 25, 2016
Manuscript received: March 10, 2016

Cite this article as

Pertynska-Marczewska M, Cypryk K. The possible impact of advanced glycation end products on pregnancy outcome in women with diabetes mellitus type 1. Minerva Endocrinol 2017;42:271-9. DOI: 10.23736/S0391-1977.16.02477-9

Corresponding author e-mail

m_pertynska@yahoo.com