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A Journal on Endocrine System Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,118
Minerva Endocrinologica 2016 December;41(4):477-85
Fasting glycemia at the first prenatal visit and pregnancy outcomes in Russian women
Polina POPOVA 1, 2, Alexandra TKACHUK 1, Alexandra DRONOVA 1, Andrey GERASIMOV 1, Ekaterina KRAVCHUK 1, Maria BOLSHAKOVA 2, Olga ROZDESTVENSKAYA 2, Ksenia DEMIDOVA 2, Alla NIKOLAEVA 3, Elena GRINEVA 1, 2 ✉
1 Institute of Endocrinology, Almazov Federal North-West Medical Research Centre, Saint Petersburg, Russia; 2 Department of Internal Diseases and Endocrinology, Saint Petersburg Pavlov State Medical University, Saint Petersburg, Russia; 3 Obstetrics and Gynecology Clinic No.22, Saint Petersburg, Russia
BACKGROUND: The aim of this study was to evaluate the associations between fasting glycemia (FG) at the first prenatal visit and adverse pregnancy outcomes.
METHODS: Medical records of 1584 pregnant women with a recorded level of FG <7 mmol/L before 24 weeks of gestation and delivery after 24 weeks were examined 823 of them underwent oral glucose tolerance test (OGTT) at 24-32 weeks of pregnancy. FG values were devided into five groups starting with <4.1 mmol/L as the first group, with subsequent increases of 0.5 mmol/L between groups and >5.6 mmol/L as the last group. The main outcomes were gestational diabetes mellitus (GDM) development, macrosomia, primary cesarean delivery, shoulder dystocia or birth injury.
RESULTS: With increasing FG levels at first prenatal visit, the frequency of GDM (among women who underwent OGTT) increased from 18.3% in the lowest category to 44.4% in the highest (odds ratio (OR) 2.94; 95% confidence interval [CI]: 1.39-6.19) and the frequency of hyperbilirubinemia increased from 4.5 to 18% respectively (OR 4.7; 95% CI: 1.8-12.5). After adjustment for maternal age and BMI, only the highest glucose category (5.6 < FG <7 mmol/L) was significantly associated with the increased risk of the above mentioned outcomes. The frequency of shoulder dystocia/birth injury (OR 24.5; 95% CI: 2.8-214.8) and preeclampsia (OR 2.7; 95% CI: 1.2-5.9) was increased in the highest glucose category compared to the intermediary categories.
CONCLUSIONS: Only the highest glucose category (5.6 < FG <7 mmol/L) at the first prenatal visit was strongly associated with some adverse pregnancy outcomes.